Is it safe to take Cymbalta if I take Fioricet(Butalbital APAP Caffeine)?

Is it safe to take Cymbalta if I take Fioricet(Butalbital APAP Caffeine)?

I take Fioricet(Butalbital APAP Caffeine) sometimes 3 to 4 tablets a day for migraines. I was prescribed Cymbalta for fibromyalgia. Is it safe to take these on the same day? I took one dose of Cymbalta at night and the next day was very dizzy while driving. I had taken the Fioricet(Butalbital APAP Caffeine) in the morning.

Best answer:

Answer by David
But, just phone a 24 hour pharmacy, like shoppers drug mart, and they will tell you definitively right away. It is very important your prescribing physician knows about all medications you take, even if they are herbal remedies.

Don’t forget you just started this med. So it will probably take 2-3 weeks for side effects to subside. Dizziness is a noted side effect.

I just looked up fioricet and it is a combination of a barbiturate, caffeine and acetaminophen.

You can note that Cymbalta puts a certain strain on the Liver, so the addition of other things that add a certain strain on the liver (i.e. fioricet) will make your liver work a bit. So, whether or not your liver is healthy or not and can handle this load, would have to be determined by your doctor. Hepatoxicity is the concern.

Here is an excerpt pertinent to you (specifically the barbiturate, which is a CNS depressant):
“CNS Acting medications — Given the primary CNS effects of Cymbalta, it should be used with caution when it is taken in combination with or substituted for other centrally acting drugs, including those with a similar mechanism of action [see Warnings and Precautions (5.11) and medication Interactions (7.17)].”

Excerpt pertinent to Caffeine:
“In vitro drug interaction studies demonstrate that duloxetine does not induce CYP1A2 activity. Therefore, an increase in the metabolism of CYP1A2 substrates (e.g., theophylline, caffeine) resulting from induction is not anticipated, although clinical studies of induction have not been performed. Duloxetine is an inhibitor of the CYP1A2 isoform in in vitro studies, and in two clinical studies the average (90% confidence interval) increase in theophylline AUC was 7% (1%-15%) and 20% (13%-27%) when co-administered with duloxetine (60 mg twice daily).”

In general:
5.11 Clinically Important medication Interactions
Both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism.
Potential for Other medications to Affect Cymbalta
CYP1A2 Inhibitors — Co-administration of Cymbalta with potent CYP1A2 inhibitors should be avoided [see medication
Interactions (7.1)].
CYP2D6 Inhibitors — Since CYP2D6 is involved in duloxetine metabolism, concomitant use of duloxetine with
potent inhibitors of CYP2D6 would be expected to, and does, result in higher concentrations (on average of 60%) of duloxetine [see medication Interactions (7.2)].”

Another Excerpt:
“7.18 medications Highly Bound to Plasma Protein
Because duloxetine is highly bound to plasma protein, administration of Cymbalta to a patient taking another drug that is highly protein bound may cause increased free concentrations of the other drug, potentially resulting in adverse reactions. However, co-administration of duloxetine (60 or 120 mg) with warfarin (2-9 mg), a highly protein-bound drug, did not result in significant changes in INR and in the pharmacokinetics of either total S-or total R-warfarin (protein bound plus free drug) [see medication Interactions (7.4)].”

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Is it safe to take fioricet while on oxycodone?

Is it safe to take fioricet while on oxycodone?
I just got my wisdom teeth out yesterday and they were bothering me so I took 3 of the 5mg oxycodones that I was prescribed. I have a migraine though and I cannot sleep. Would it be safe for me to take fioricet to help with the migraine?

Best answer:

Answer by John Doe
I do sometimes myself, but I wouldnt take more then one of each due to the amount of Acetaminophen.
Fioricet has 325mg of acetaminophen, and it depends on what type of oxycodone drug your on, some contain 325mg, and some have 650mg’s, or if it’s oxycontin it wont have any acetaminophen at all, just try not to ecceed more then 650 mg of acetaminophen in a 3 hour period.

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What kind of pain drug can i take with fioricet?

What kind of pain drug can i take with fioricet?
My doctor prescibe fioricet for migrains and my dentist prescibed lortabs for my toothache ,i cannot take them together .MY problem is the lortab helps with the toothache but not the headache and thefioricet helps with the head ache but not the toothache.I have a doctors appointment on friday i am hoping she canhelp with this problem…any advise.?

Best answer:

Answer by Mary Soilex





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I take Wellbutrin, Alprazolam and Fioricet at the same time?

I can Wellbutrin, Alprazolam and Fioricet at the same time?
Or if not all the same time I usually take Wellbutrin every morning if needed alprazolam for anxiety and Fioricet if necessary. Is it safe Best Answer:

reaction S
Yes, that’s fine. In the future, call a pharmacist and ask. They are a wonderful resource for free information like this.

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How many pain relief tablets does it take to kill you?

How many pain relief tablets does it take to kill you?
I don’t to take too many pain relief tablets so i was wondering about how many pain relief tablets do you have to take to kill yourself.

AND NO I’M NOT SUICIDAL. I am just scared that i might accidentally take too much.

Best answer:

How many times has someone told you a “party” drug could lead to more serious problems – like addiction, brain damage, or even death? You’ve probably heard it so many times, it’s getting hard to believe. But all drugs have real potential for harm – even prescription pain relievers. When abused alone, or taken with other drugs, prescription pain medications can kill you. And the death toll from misuse and abuse is rising steadily.

Think twice-because you only die once. Prescription pain relievers, when used correctly and under a doctor’s supervision, are safe and effective. But abuse them, or mix them with illegal drugs or alcohol, and you could wind up in the morgue. Even using prescription pain relievers with other prescription drugs (such as antidepressants) or over-the-counter medications (like cough syrups and antihistamines), can lead to life-threatening respiratory failure. With some prescription pain relievers, all it takes is one pill.

Drugs to watch out for. The most dangerous prescription pain relievers are those containing drugs known as opioids, such as morphine and codeine. Some common drugs containing these substances include:

  • propoxyphene (Darvon),
  • meperidine (Demerol),
  • guaifenesin with hydromorphone (Dilaudid),
  • oxycodone (OxyContin),
  • Tylenol with Codeine, and
  • hydrocodone/acetaminophen (Vicodin, Norco, etc.).

Some common street names for these drugs include:

  • ac/dc,
  • blue,
  • 40,
  • 80,
  • coties,
  • demmies,
  • dillies,
  • hillbilly heroin,
  • o.c.,
  • oxy,
  • oxycotton,
  • percs, and
  • vics.

Whatever you call them, remember one thing – they can be killers.

Symptoms of overdose.

If you, or anyone you know, have taken prescription pain relievers, here are the danger signs to watch for:

  • Slow breathing (less than ten breaths a minute is really serious trouble)
  • Small, pinpoint pupils
  • Confusion
  • Being tired, nodding off, or passing out
  • Dizziness
  • Weakness
  • Apathy (they don’t care about anything)
  • Cold and clammy skin
  • Nausea
  • Vomiting
  • Seizures

A lot of these symptoms can make people think the person is drunk. Some people may be tempted to let the person sleep it off, or think they just had too much to drink. But don’t. Your friend could go to sleep and never wake up.

What you can do if a friend is overdosing. Make an anonymous call to 911 if you do not want to identify yourself. Try to get the person to respond to you by calling out his/her name. Make the person wake up and talk to you. Shake him/her if you have to. Otherwise, the individual could suffer brain damage, fall into a coma, or die.

Addiction can be a living death. If you abuse prescription pain relievers and are lucky enough to cheat death, you’re still in big trouble. Prescription pain relievers can be addictive. The longer you take them, the more your body needs. Try to stop, and you could experience withdrawal symptoms.

Addiction to prescription pain relievers is like being hooked on heroin and the withdrawal isn’t much different: bone and muscle pain, diarrhea, vomiting, cold flashes, and insomnia.

If you, or someone you know, is abusing or is addicted, get professional help. You can also ask for help from parents, doctors, relatives, teachers, or school guidance counselors. Substance abuse ruins lives. Don’t let it happen to you or someone you love.

If you, or someone you know, is hooked on prescription pain relievers, call the substance abuse treatment 24-hour helpline: 1.800.662.HELP, or visit the Substance Abuse and Mental Health website,

Is it a good idea to take pain relief drug while doing a football condition?

Is it a good idea to take pain relief drug while doing a football condition?

I have muscle pain in my knee and both of my arms probably from running and weightlifting. Is it a good idea to take pain relief drug while im doing football conditions

Best answer:

Answer by msmer m
It should be alright to take an anti inflamatory like ibuprofen or tylenol, which will not alter your mental status. but you may want to avoid any norcotic medication, drink lots of fluids to avoid dehydration of the muscle.

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