Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking Fioricet with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may interact with Fioricet, including prescription and over-the-counter medicines, vitamins, and herbal products.
Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Most frequently checked interactions
View interaction reports for Fioricet (acetaminophen / butalbital / caffeine) and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Advil (ibuprofen)
- Ambien (zolpidem)
- aspirin
- Ativan (lorazepam)
- baclofen
- caffeine
- clonazepam
- codeine
- Cymbalta (duloxetine)
- Excedrin (acetaminophen / aspirin / caffeine)
- Flexeril (cyclobenzaprine)
- gabapentin
- hydrocodone
- ibuprofen
- ibuprofen
- Imitrex (sumatriptan)
- Klonopin (clonazepam)
- levothyroxine
- Lexapro (escitalopram)
- lisinopril
- Lyrica (pregabalin)
- meloxicam
- naproxen
- Norco (acetaminophen / hydrocodone)
- omeprazole
- oxycodone
- Percocet (acetaminophen / oxycodone)
- prednisone
- Suboxone (buprenorphine / naloxone)
- Topamax (topiramate)
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
What other drugs could interact with this medication?
There may be an interaction between ASA – caffeine – butalbital and any of the following:
- abiraterone
- acetazolamide
- alcohol
- alendronate
- amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
- angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartan, losartan)
- angiotensin converting enzyme inhibitors (ACEIs; e.g., captopril, ramipril)
- antihistamines (e.g., chlorpheniramine, diphenhydramine, doxylamine)
- antipsychotic medications (e.g., chlorpromazine, haloperidol, quetiapine, risperidone)
- apixaban
- atomoxetine
- azelastine
- other barbiturates (e.g., butalbital, pentobarbital phenobarbital)
- benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
- beta-blockers (e.g., atenolol, propranolol)
- birth control pills
- brimonidine
- fast acting bronchodilators (e.g., salbutamol, terbutaline)
- long acting bronchodilators (e.g., formoterol, indacaterol, salmeterol)
- buprenorphine
- buspirone
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- cannabis
- celecoxib
- chloral hydrate
- clopidogrel
- corticosteroids (e.g., prednisone)
- cyclosporine
- dabigatran
- dasatinib
- decongestant cold medications (e.g., phenylephrine, pseudoephedrine)
- decongestant eye drops and nose sprays (e.g., naphazoline, oxymetazoline, xylometazoline)
- deferasirox
- diabetes medications (e.g., chlorpropamide, glipizide, glyburide, insulin, metformin, rosiglitazone)
- dipivefrin
- disopyramide
- diuretics (water pills; e.g., furosemide, hydrochlorothiazide, spironolactone)
- edoxaban
- efavirenz
- epinephrine
- estrogens
- ginkgo biloba
- glucosamine
- heparin
- imatinib
- kava kava
- levonorgestrel
- linezolid
- lithium
- low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
- mercaptopurine
- methadone
- methotrexate
- methoxsalen
- methylphenidate
- mexiletine
- mirtazapine
- modafinil
- monoamine oxidase inhibitors (MAOIs e.g., moclobemide, phenelzine, tranylcypromine)
- muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine, tizanadine)
- nabilone
- narcotic pain relievers (e.g., codeine, fentanyl, morphine)
- nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
- nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, ketorolac, naproxen)
- olopatadine
- omega-3 fatty acids
- pentoxifylline
- pramipexole
- prasugrel
- pyridoxine
- quinine
- quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, moxifloxacin)
- rifampin
- rifabutin
- rivaroxaban
- ropinirole
- rotigotine
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, sertraline)
- seizure medications (e.g., clobazam, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- serotonin/norepinephrine reuptake inhibitors (e.g., desvenlafaxine, duloxetine, venlafaxine)
- somatostatin
- sulfinpyrazone
- tapentadol
- teniposide
- teriflunomide
- tetracaine
- tetracyclines (e.g., doxycycline, minocycline, tetracycline)
- thalidomide
- theophyllines (e.g., aminophylline, oxtriphylline, theophylline)
- ticagrelor
- ticlopidine
- tramadol
- tricyclic antidepressants (e.g., amitriptyline, desipramine, nortriptyline)
- ulipristal
- vaccines
- vemurafenib
- voriconazole
- warfarin
- zolpidem
- zopiclone
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.